The future of the wild oyster fishery in the northern Gulf of Mexico is largely uncertain due to changing environmental conditions and declining abundance of harvestable oysters. Specifically, rising temperatures can directly impact the physiological thresholds of the eastern oyster (Crassostrea virginica) at all life history stages and alter the narrow ecological niche this oyster occupies. The impact of rising temperatures is likely most pronounced during atmospheric heatwaves, defined as three or more days above the 90th percentile of daily maximum air temperatures, which have been shown to be increasing in frequency. Increasing exposure to high temperature extremes may contribute to and exacerbate an already declining oyster fishery. Critical to fishery health is recruitment i.e., the addition of new harvestable biomass, which is a dynamic process strongly driven by temperature. Here, we examine the relationship between heatwave characteristics and the prediction of poor oyster recruitment, measured as the abundance of post-larval oysters (e.g. spat) below the site-specific median density observed in historically productive oyster fisheries over 46-years (1976 – 2020) in Mobile Bay, Alabama and 21-years (1993 – 2014) in Apalachicola Bay, Florida. We acquired daily maximum air temperature measurements measured over 50 years (1970 – 2020) at weather monitoring stations adjacent to the bays to identify site specific annual heatwave events (maximum yearly air temperature, yearly and consecutive heatwave days, and number of annual heatwaves). Then, years with extreme heatwaves that exceeded the 75th percentile for the 50-year measurements were compared to years with non-extreme heatwave events. Years with extreme total heatwave days and extreme consecutive heatwave days were correlated with low post-larval oyster density. Across both bay systems, if consecutive heatwave days exceeded 11 days, then poor recruitment of oysters occurred 83 % of the time. Extreme heatwave duration as an indicator for poor recruitment has the potential to be a powerful tool for fishery managers to forecast recruitment and inform sustainable oyster harvest based on year-to-year variability in heatwave duration and long-term warming trends. Our findings illustrate how extreme temperatures can exacerbate multiple physiological and ecological stressors resulting in the loss of a keystone species for healthy and resilient coastal ecosystems.