Trichothiazole A, a dichlorinated polyketide containing an embedded thiazole isolated from Trichodesmium blooms

Belisle, Richard S.; Via, Christopher W.; Schock, Tracey B.; Villareal, Tracy A.; Zimba, Paul V.; Beauchesne, Kevin R.; Moeller, Peter D.R.; Bertin, Matthew J.

doi:10.1016/j.tetlet.2017.09.027

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Trichothiazole A, a dichlorinated polyketide containing an embedded thiazole isolated from Trichodesmium blooms

2017
By Belisle, Richard S. ; Via, Christopher W. ; Schock, Tracey B. ; ...
Source: Tetrahedron Letters, 58(43), 4066-4068

[PDF-1.37 MB]

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Tetrahedron Letters
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Belisle, Richard S. ; Via, Christopher W. ; Schock, Tracey B. ; Villareal, Tracy A. ; Zimba, Paul V. ; ... More +

Belisle, Richard S. ; Via, Christopher W. ; Schock, Tracey B. ; Villareal, Tracy A. ; Zimba, Paul V. ; Beauchesne, Kevin R. ; Moeller, Peter D.R. ; Bertin, Matthew J. Less -
NOAA Program & Office:

NCCOS (National Centers for Coastal Ocean Science) ; NOS (National Ocean Service)

NCCOS (National Centers for Coastal Ocean Science) ; NOS (National Ocean Service) Less -
Description:

Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2 A cells (EC50: 13.3 ± 1.1 μM).
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Biochemistry Drug Discovery Organic Chemistry
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Tetrahedron Letters, 58(43), 4066-4068
DOI:

https://doi.org/10.1016/j.tetlet.2017.09.027
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0040-4039
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PDF
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Elsevier BV
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Journal Article
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urn:sha-512:6453f586448b1f0ed1c6d312049df45453d94c8deca1bb7430d70f58e0be82c5e39fe7a15b1146322f44823fede12ec1846ab77800f28a4824272e73989ffc9e
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Trichothiazole A, a dichlorinated polyketide containing an embedded thiazole isolated from Trichodesmium blooms

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