Sublethal neurotoxicity of organophosphate insecticides to juvenile coho salmon

Laetz, Cathy A.; Baldwin, David H.; Scholz, Nathaniel L.

doi:10.1016/j.aquatox.2020.105424

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i

Sublethal neurotoxicity of organophosphate insecticides to juvenile coho salmon

2020
By Laetz, Cathy A. ; Baldwin, David H. ; Scholz, Nathaniel L.
Source: Aquatic Toxicology, 221, 105424

[PDF-372.08 KB]

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Journal Title:

Aquatic Toxicology
Personal Author:

Laetz, Cathy A. ; Baldwin, David H. ; Scholz, Nathaniel L.

Laetz, Cathy A. ; Baldwin, David H. ; Scholz, Nathaniel L. Less -
NOAA Program & Office:

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center)

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center) Less -
Description:

For decades, organophosphate (OP) insecticides have been used as chemical control agents in watersheds that support at-risk populations of Pacific salmon throughout western North America. Spray drift, runoff, and other processes transport OPs to critical surface water habitats for migratory salmonids. While most OPs share a common mechanism of action (i.e., inhibition of neuronal acetylcholinesterase, or AChE), they typically vary in toxic potency. Moreover, dose-response relationships for exposure and sublethal neurotoxicity (e.g., brain AChE inhibition) in salmonids have not been defined for many OPs. Here we exposed juvenile coho salmon (Oncorhynchus kisutch) to five common anticholinesterase insecticides (dimethoate, ethoprop, naled, phorate and phosmet) that are widely used on agricultural, commercial, residential, and public lands. Each of the five pesticides produced a concentration-dependent inhibition of AChE enzyme activity. The effective concentration for 50 % AChE inhibition (96-hr EC50) indicated the highest toxicity for phorate (EC50 = 0.57 μg/L) followed by phosmet (3.3 μg/L), naled (7.8 μg/L), ethoprop (90.6 μg/L) and dimethoate (273 μg/L). These findings can inform 1) relative hazard analyses for OP use near sensitive aquatic habitats, 2) predictions of sublethal OP mixture toxicity, and 3) ecological risk assessments for threatened or endangered species of Pacific salmon.
Keywords:

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Aquatic Science Health, Toxicology And Mutagenesis
Source:

Aquatic Toxicology, 221, 105424
DOI:

https://doi.org/10.1016/j.aquatox.2020.105424
ISSN:

0166-445X
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PDF
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Elsevier BV
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Journal Article
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urn:sha-512:7fc17a1c7d0ecaa5770a95e9f8c48954d2a79f3f490cd7e7381248af7b6f4c8b143d690dba3981b3be601221b2c1ba3492b25c01dc19d9512024080968173979
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Sublethal neurotoxicity of organophosphate insecticides to juvenile coho salmon

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