Metabolomic Insights of the Effects of Bacterial Algicide IRI-160AA on Dinoflagellate Karlodinium veneficum

Wang, Yanfei; Coyne, Kathryn J.

doi:10.3390/metabo12040317

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The NOAA IR serves as an archival repository of NOAA-published products including scientific findings, journal articles, guidelines, recommendations, or other information authored or co-authored by NOAA or funded partners. As a repository, the NOAA IR retains documents in their original published format to ensure public access to scientific information.

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Metabolomic Insights of the Effects of Bacterial Algicide IRI-160AA on Dinoflagellate Karlodinium veneficum

2022
By Wang, Yanfei ; Coyne, Kathryn J.
Source: Metabolites, 12(4), 317

[PDF-2.36 MB]

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Details:

Journal Title:

Metabolites
Personal Author:

Wang, Yanfei ; Coyne, Kathryn J.

Wang, Yanfei ; Coyne, Kathryn J. Less -
NOAA Program & Office:

NOS (National Ocean Service)
Description:

Shewanella sp. IRI-160 is an algicidal bacterium that secretes an algicide, IRI-160AA. This algicide specifically targets dinoflagellates, while having no adverse effects on other algal species tested. Dinoflagellates exposed to IRI-160AA exhibited increased production of reactive oxygen species (ROS), DNA damage, and cell cycle arrest, implying a programmed pathway leading to cell death (PCD). Here, a metabolomic analysis was conducted on dinoflagellate Karlodinium veneficum and a control cryptophyte species Rhodomonas exposed to IRI-160AA to investigate the cellular mechanisms behind the physiological effects and the specificity of this algicide. Results of this research supported previous observations about physiological responses to the algicide. A suite of metabolites was identified that increased in the cell pellets of K. veneficum but not in Rhodomonas, including oxidative stress biomarkers, antioxidants, and compounds involved in DNA damage and PCD. Overall, the results of this study illustrated the metabolomic mechanisms underlying the algicidal effects of IRI-160AA on dinoflagellates. This research also provided insights and future directions for studies on the cellular response of dinoflagellates exposed to antagonistic bacteria in the environment.
Keywords:

[+]

Biochemistry Endocrinology, Diabetes And Metabolism Molecular Biology
Source:

Metabolites, 12(4), 317
DOI:

https://doi.org/10.3390/metabo12040317
ISSN:

2218-1989
Format:

PDF
Publisher:

MDPI AG
Document Type:

Journal Article
Funding:

Grant no. NA15NOS4780176 ; Grant no. NA20NOS4780185

Grant no. NA15NOS4780176 ; Grant no. NA20NOS4780185 Less -
License:

https://creativecommons.org/licenses/by/4.0/
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CC BY
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Library
Main Document Checksum:

[+]

urn:sha256:a6974768a4f30c76bcd3182d356161fb6bc50434fdad83e1a75d324011d5bf5d
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https://repository.library.noaa.gov/view/noaa/58695/noaa_58695_DS1.pdf
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Metabolomic Insights of the Effects of Bacterial Algicide IRI-160AA on Dinoflagellate Karlodinium veneficum

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