Biosynthesis of marine toxins

Chekan, Jonathan R.; Fallon, Timothy R.; Moore, Bradley S.

doi:10.1016/j.cbpa.2020.06.009

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Biosynthesis of marine toxins

2020
By Chekan, Jonathan R. ; Fallon, Timothy R. ; Moore, Bradley S.
Source: Current Opinion in Chemical Biology, 59, 119-129

[PDF-830.01 KB]

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Journal Title:

Current Opinion in Chemical Biology
Personal Author:

Chekan, Jonathan R. ; Fallon, Timothy R. ; Moore, Bradley S.

Chekan, Jonathan R. ; Fallon, Timothy R. ; Moore, Bradley S. Less -
NOAA Program & Office:

NOS (National Ocean Service)
Description:

Throughout history, humans have encountered natural toxic chemicals from the ocean environment, often through contaminated seafood. Although marine toxins can be harmful to human health and devastate local environments when they are produced during algal bloom events, they are also important biochemical research reagents and drug leads in medicine. In spite of their long history, the biosynthetic origin of many well-known marine toxins has remained elusive. New biosynthetic insights have shed light on the chemical transformations that create the complex structures of several iconic oceanic toxins. To that end, this review highlights advances made in the biosynthetic understanding of five important environmental toxins of marine origin: domoic acid, kainic acid, saxitoxin, tetrodotoxin, and polyether polyketides such as brevetoxin.
Keywords:

[+]

Analytical Chemistry Biochemistry
Source:

Current Opinion in Chemical Biology, 59, 119-129
DOI:

https://doi.org/10.1016/j.cbpa.2020.06.009
ISSN:

1367-5931
Format:

PDF
Publisher:

Elsevier BV
Document Type:

Journal Article
Funding:

Grant no. NA19NOS4780181
Rights Information:

Accepted Manuscript
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Library
Main Document Checksum:

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urn:sha256:8964b4970957bf9d10f86e8ee18d3cc30fb0751fde232a97c419f61e8da12215
Download URL:

https://repository.library.noaa.gov/view/noaa/57771/noaa_57771_DS1.pdf
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Biosynthesis of marine toxins

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