Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence

Petroff, R.; Hendrix, A.; Shum, S.; Grant, K.S.; Lefebvre, K.A.; Burbacher, T.M.

doi:10.1016/j.pharmthera.2021.107865

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The NOAA IR serves as an archival repository of NOAA-published products including scientific findings, journal articles, guidelines, recommendations, or other information authored or co-authored by NOAA or funded partners. As a repository, the NOAA IR retains documents in their original published format to ensure public access to scientific information.

i

Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence

2021
By Petroff, R. ; Hendrix, A. ; Shum, S. ; ...
Source: Pharmacology & Therapeutics 227 (2021) 107865

[PDF-1.06 MB]

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Details:

Journal Title:

Pharmacology & Therapeutics
Personal Author:

Petroff, R. ; Hendrix, A. ; Shum, S. ; Grant, K.S. ; Lefebvre, K.A. ; ... More +

Petroff, R. ; Hendrix, A. ; Shum, S. ; Grant, K.S. ; Lefebvre, K.A. ; Burbacher, T.M. Less -
NOAA Program & Office:

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center)

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center) Less -
Description:

Domoic acid (DA), the causative agent for the human syndrome Amnesic Shellfish Poisoning (ASP), is a potent, naturally occurring neurotoxin produced by common marine algae. DA accumulates in seafood, and humans and wildlife alike can subsequently be exposed when consuming DA-contaminated shellfish or finfish. While strong regulatory limits protect people from the acute effects associated with ASP, DA is an increasingly significant public health concern, particularly for coastal dwelling populations, and there is a growing body of evidence suggesting that there are significant health consequences following repeated exposures to levels of the toxin below current safety guidelines. However, gaps in scientific knowledge make it difficult to precisely determine the risks of contemporary low-level exposure scenarios. The present review characterizes the toxicokinetics and neurotoxicology of DA, discussing results from clinical and preclinical studies after both adult and developmental DA exposure. The review also highlights crucial areas for future DA research and makes the case that DA safety limits need to be reassessed to best protect public health from deleterious effects of this widespread marine toxin.
Keywords:

[+]

Amnesic Shellfish Poisoning Domoic Acid Public Health Chronic Exposure Development Neurotoxicity
Source:

Pharmacology & Therapeutics 227 (2021) 107865
DOI:

https://doi.org/10.1016/j.pharmthera.2021.107865
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urn:sha256:a1b3e18b0ad557f6be52622f4cce616f4f6e7116f3c8d0729e0d76e0ff1854f9
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