Skin Transcriptomes of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts

Neely, Marion G.; Morey, Jeanine S.; Anderson, Paul; Balmer, Brian C.; Ylitalo, Gina M.; Zolman, Eric S.; Speakman, Todd R.; Sinclair, Carrie; Bachman, Melannie J.; Huncik, Kevin; Kucklick, John; Rosel, Patricia E.; Mullin, Keith D.; Rowles, Teri K.; Schwacke, Lori H.; Van Dolah, Frances M.

doi:10.1016/j.margen.2017.08.002

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Skin Transcriptomes of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts

2018
By Neely, Marion G. ; Morey, Jeanine S. ; Anderson, Paul ; ...
Source: Marine Genomics, 38, 45-58

[PDF-1.60 MB]

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Journal Title:

Marine Genomics
Personal Author:

Neely, Marion G. ; Morey, Jeanine S. ; Anderson, Paul ; Balmer, Brian C. ; Ylitalo, Gina M. ; ... More +

Neely, Marion G. ; Morey, Jeanine S. ; Anderson, Paul ; Balmer, Brian C. ; Ylitalo, Gina M. ; Zolman, Eric S. ; Speakman, Todd R. ; Sinclair, Carrie ; Bachman, Melannie J. ; Huncik, Kevin ; Kucklick, John ; Rosel, Patricia E. ; Mullin, Keith D. ; Rowles, Teri K. ; Schwacke, Lori H. ; Van Dolah, Frances M. Less -
NOAA Program & Office:

NMFS (National Marine Fisheries Service) ; SEFSC (Southeast Fisheries Science Center) ; NWFSC (Northwest Fisheries Science Center) ; OPR (Office of Protected Resources) ; NOS (National Ocean Service) ; ... More +

NMFS (National Marine Fisheries Service) ; SEFSC (Southeast Fisheries Science Center) ; NWFSC (Northwest Fisheries Science Center) ; OPR (Office of Protected Resources) ; NOS (National Ocean Service) ; NCCOS (National Centers for Coastal Ocean Science) Less -
Description:

Common bottlenose dolphins serve as sentinels for the health of their coastal environments as they are susceptible to health impacts from anthropogenic inputs through both direct exposure and food web magnification. Remote biopsy samples have been widely used to reveal contaminant burdens in free-ranging bottlenose dolphins, but do not address the health consequences of this exposure. To gain insight into whether remote biopsies can also identify health impacts associated with contaminant burdens, we employed RNA sequencing (RNA-seq) to interrogate the transcriptomes of remote skin biopsies from 116 bottlenose dolphins from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts. Gene expression was analyzed using principal component analysis, differential expression testing, and gene co-expression networks, and the results correlated to season, location, and contaminant burden. Season had a significant impact, with over 60% of genes differentially expressed between spring/summer and winter months. Geographic location exhibited lesser effects on the transcriptome, with 23.5% of genes differentially expressed between the northern Gulf of Mexico and the southeastern U.S. Atlantic locations. Despite a large overlap between the seasonal and geographical gene sets, the pathways altered in the observed gene expression profiles were somewhat distinct. Co-regulated gene modules and differential expression analysis both identified epidermal development and cellular architecture pathways to be expressed at lower levels in animals from the northern Gulf of Mexico. Although contaminant burdens measured were not significantly different between regions, some correlation with contaminant loads in individuals was observed among co-expressed gene modules, but these did not include classical detoxification pathways. Instead, this study identified other, possibly downstream pathways, including those involved in cellular architecture, immune response, and oxidative stress, that may prove to be contaminant responsive markers in bottlenose dolphin skin.
Keywords:

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Bottlenose Dolphins Genetics Marine Biology
Source:

Marine Genomics, 38, 45-58
DOI:

https://doi.org/10.1016/j.margen.2017.08.002
ISSN:

1874-7787
Format:

PDF
Publisher:

Elsevier BV
Document Type:

Journal Article
Place as Subject:

Mexico, Gulf of ; Atlantic Ocean

Mexico, Gulf of ; Atlantic Ocean Less -
License:

https://creativecommons.org/licenses/by/4.0/
Rights Information:

CC BY
Compliance:

Submitted
Main Document Checksum:

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urn:sha256:4a06d259316f4a6f6c35172b40b5dc6571823b92d7b649282e6f914696526c0e
Download URL:

https://repository.library.noaa.gov/view/noaa/51775/noaa_51775_DS1.pdf
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Skin Transcriptomes of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts

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