Expanded Phylogenetic Diversity And Metabolic Flexibility Of Mercury-Methylating Microorganisms

Mcdaniel, Elizabeth A.; Peterson, Benjamin D.; Stevens, Sarah L. R.; Tran, Patricia Q.; Anantharaman, Karthik; Mcmahon, Katherine D.

doi:10.1128/mSystems.00299-20

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Expanded Phylogenetic Diversity And Metabolic Flexibility Of Mercury-Methylating Microorganisms

2020
By Mcdaniel, Elizabeth A. ; Peterson, Benjamin D. ; Stevens, Sarah L. R. ; ...
Source: mSystems. 2020 Jul-Aug; 5(4): e00299-20.

[PDF-4.19 MB]

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Journal Title:

mSystems
Personal Author:

Mcdaniel, Elizabeth A. ; Peterson, Benjamin D. ; Stevens, Sarah L. R. ; Tran, Patricia Q. ; Anantharaman, Karthik ; ... More +

Mcdaniel, Elizabeth A. ; Peterson, Benjamin D. ; Stevens, Sarah L. R. ; Tran, Patricia Q. ; Anantharaman, Karthik ; Mcmahon, Katherine D. Less -
NOAA Program & Office:

Sea Grant ; OAR (Oceanic and Atmospheric Research)

Sea Grant ; OAR (Oceanic and Atmospheric Research) Less -
Sea Grant Program:

WISCU (Wisconsin Sea Grant)
Description:

Methylmercury is a potent bioaccumulating neurotoxin that is produced by specific microorganisms that methylate inorganic mercury. Methylmercury production in diverse anaerobic bacteria and archaea was recently linked to the hgcAB genes. However, the full phylogenetic and metabolic diversity of mercury-methylating microorganisms has not been fully unraveled due to the limited number of cultured experimentally verified methylators and the limitations of primer-based molecular methods. Here, we describe the phylogenetic diversity and metabolic flexibility of putative mercury-methylating microorganisms by hgcAB identification in publicly available isolate genomes and metagenome-assembled genomes (MAGs) as well as novel freshwater MAGs. We demonstrate that putative mercury methylators are much more phylogenetically diverse than previously known and that hgcAB distribution among genomes is most likely due to several independent horizontal gene transfer events. The microorganisms we identified possess diverse metabolic capabilities spanning carbon fixation, sulfate reduction, nitrogen fixation, and metal resistance pathways. We identified 111 putative mercury methylators in a set of previously published permafrost metatranscriptomes and demonstrated that different methylating taxa may contribute to hgcA expression at different depths. Overall, we provide a framework for illuminating the microbial basis of mercury methylation using genome-resolved metagenomics and metatranscriptomics to identify putative methylators based upon hgcAB presence and describe their putative functions in the environment.
Keywords:

[+]

Genomics Mercury Methylmercury
Source:

mSystems. 2020 Jul-Aug; 5(4): e00299-20.
DOI:

https://doi.org/10.1128/mSystems.00299-20
Pubmed ID:

32817383
Pubmed Central ID:

PMC7438021
Document Type:

Journal Article
Funding:

Grant no. NA14OAR4170092
Rights Information:

CC BY
Compliance:

PMC
Main Document Checksum:

[+]

urn:sha256:3f9f51952cefcba1ed770abad1a4dcea250fa8840c24d36ee014f37eacbcd2c6
Download URL:

https://repository.library.noaa.gov/view/noaa/27648/noaa_27648_DS1.pdf
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Expanded Phylogenetic Diversity And Metabolic Flexibility Of Mercury-Methylating Microorganisms

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