Details:

Journal Title:
NeuroToxicology
Personal Author:
Golding, Jean ; Gregory, Steven ; Emond, Alan ; Iles-Caven, Yasmin ; Hibbeln, Joseph ; ... More +
Golding, Jean ; Gregory, Steven ; Emond, Alan ; Iles-Caven, Yasmin ; Hibbeln, Joseph ; Taylora, Caroline M. Less -
Description:
Background: There is considerable discussion over the possible harm caused by fetal exposure to mercury, but evidence of such harm is contradictory at levels commonly found in populations with moderate intakes of fish. Further information is needed to inform debate and clarify policy recommendations.

Material: Data were collected prospectively for the Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood taken in the first half of pregnancy was assayed for mercury. The outcomes were offspring behavioural assessments collected using the Strengths and Difficulties Questionnaire at seven time points between ages 4 and 16–17 years; five were completed by the mother and two by the teacher. Socioeconomic and biological confounders were first taken into account; further analyses added maternal blood selenium. Separate analyses compared the relationships between prenatal mercury levels and behaviour traits treated as continuous measures in women who ate fish with those who ate no fish in order to determine whether the relationships differed; the hypothesis was that fish consumption had benefits on the brain and masked any mercury effects. In order to prevent Type II errors, the P value for significance was set at 0.10.


Keywords:
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Mercury
Toxicology

Source:
eurotoxicology. 2016 Dec; 57: 87–94.
DOI:
http://dx.doi.org/10.1016/j.neuro.2016.09.003
Pubmed ID:
27633321
Pubmed Central ID:
PMC5138154
Document Type:
Journal Article
Rights Information:
CC BY
Compliance:
PMC
Main Document Checksum:
[+]
urn:sha256:7a2ed2b207877078bba1d25cd98ba122c607d4ec2a37baacd00fa1fcae1e6445
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