i
Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom
-
2017
-
-
Source: Mar. Drugs, 15(1), 1-8
Details:
-
Journal Title:Marine Drugs
-
Personal Author:
-
NOAA Program & Office:
-
Description:In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6.5 μM) and HCT-116 cells (EC50: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds.
-
Keywords:
-
Source:Mar. Drugs, 15(1), 1-8
-
DOI:
-
Pubmed Central ID:PMC5295230
-
Document Type:
-
Rights Information:CC BY
-
Compliance:PMC
-
Main Document Checksum:
-
Download URL:
-
File Type: