Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom

Details

• Journal Title:
  Marine Drugs
• Personal Author:
  Bertin, Matthew ; Wahome, Paul ; Zimba, Paul ; He, Haiyin ; Moeller, Peter
• NOAA Program & Office:
  NOS (National Ocean Service)
• Description:
  In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6.5 μM) and HCT-116 cells (EC50: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds.
• Keywords:
  Cyanobacterial Blooms Polyketides Research Toxicology Cyanobacterial Blooms
• Source:
  Mar. Drugs, 15(1), 1-8
• DOI:
  https://doi.org/10.3390/md15010010
• Pubmed Central ID:
  PMC5295230
• Document Type:
  Journal Article
• Rights Information:
  CC BY
• Compliance:
  PMC
• Main Document Checksum:
  urn:sha-512:10431536007c2d21d356b5a9ed9254832c2abe12bb2312eeb49d1a5a930e4fcedaf7a2e6722a95d2ed448e491c2eba9a8e5e98f8f7c7122d67b2f7ba150b2693
• Download URL:
  https://repository.library.noaa.gov/view/noaa/25616/noaa_25616_DS1.pdf
• File Type:
  [PDF - 904.61 KB ]