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i

Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides Brasiliensis



Details

  • Journal Title:
    Emerging Infectious Diseases
  • Personal Author:
    Vilela, Raquel ; Bossart, Gregory D. ; St. Leger, Judy A. ; Dalton, Leslie M. ; Reif, John S. ; Schaefer, Adam M. ; McCarthy, Peter J. ; Fair, Patricia A. ; Mendoza, Leonel
  • NOAA Program & Office:
    NOS (National Ocean Service) ; NCCOS (National Centers for Coastal Ocean Science)
  • Description:
    Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
  • Source:
    Emerg Infect Dis ; . 2016 Dec;22(12):2063-2069.
  • DOI:
    https://doi.org/10.3201/eid2212.160860
  • Pubmed Central ID:
    PMC5189160
  • Document Type:
    Journal Article
  • Rights Information:
    Other
  • Compliance:
    PMC
  • Download URL:
    https://repository.library.noaa.gov/view/noaa/24358/noaa_24358_DS1.pdf
  • File Type:
    Filetype[PDF - 2.08 MB]
  • Collection(s):
    National Ocean Service (NOS)
  • Main Document Checksum:
    urn:sha-512:cee5a42e33c418ca163caee64d9d42e6bb975d89f9da6533aa543630dc1a7fc61b0c6388bcf88f3c3cde22f059a049cb95b89d92685752c114b7076b802ee002
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