Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides Brasiliensis

Vilela, Raquel; Bossart, Gregory D.; St. Leger, Judy A.; Dalton, Leslie M.; Reif, John S.; Schaefer, Adam M.; McCarthy, Peter J.; Fair, Patricia A.; Mendoza, Leonel

doi:10.3201/eid2212.160860

i

Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides Brasiliensis

2016
By Vilela, Raquel ; Bossart, Gregory D. ; St. Leger, Judy A. ; ...

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Journal Title:

Emerging Infectious Diseases
Personal Author:

Vilela, Raquel ; Bossart, Gregory D. ; St. Leger, Judy A. ; Dalton, Leslie M. ; Reif, John S. ; Schaefer, Adam M. ; McCarthy, Peter J. ; Fair, Patricia A. ; Mendoza, Leonel
NOAA Program & Office:

NOS (National Ocean Service) ; NCCOS (National Centers for Coastal Ocean Science)
Description:

Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
Keywords:

Bottlenose Dolphins Diseases Bottlenose Dolphins
Source:

Emerg Infect Dis ; . 2016 Dec;22(12):2063-2069.
DOI:

https://doi.org/10.3201/eid2212.160860
Pubmed Central ID:

PMC5189160
Document Type:

Journal Article
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Other
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PMC
Main Document Checksum:

urn:sha-512:cee5a42e33c418ca163caee64d9d42e6bb975d89f9da6533aa543630dc1a7fc61b0c6388bcf88f3c3cde22f059a049cb95b89d92685752c114b7076b802ee002
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https://repository.library.noaa.gov/view/noaa/24358/noaa_24358_DS1.pdf
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[PDF - 2.08 MB ]

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