Determination of microcystins and nodularins in ambient freshwater and seawater by liquid chromatography-mass spectrometry including toxin screening and identification

Wang, Zhihong; Mikulski, Christina M.; Kent, Makayla; Leighfield, Tod; Doucette, Gregory J.; Ramsdell, John S.

doi:10.1016/j.aca.2024.343449

i

Determination of microcystins and nodularins in ambient freshwater and seawater by liquid chromatography-mass spectrometry including toxin screening and identification

2025
By Wang, Zhihong ; Mikulski, Christina M. ; Kent, Makayla ; ...

Details

Journal Title:

Analytica Chimica Acta
Personal Author:

Wang, Zhihong ; Mikulski, Christina M. ; Kent, Makayla ; Leighfield, Tod ; Doucette, Gregory J. ; Ramsdell, John S.
NOAA Program & Office:

NOS (National Ocean Service) ; NCCOS (National Centers for Coastal Ocean Science)
Description:

Microcystins (MCs) and nodularins (NODs) produced by cyanobacteria occur in ambient freshwaters and across the freshwater-marine continuum, and pose health threats through drinking and recreational waters, as well as food resources. Approximately 300 MC and NOD toxins have been published, but less than 15 of them are commercially available as toxin standards. Our aim herein was to rapidly identify and quantify all toxin congeners, including those without standards, in water samples even at low abundance by reversed-phase solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) to provide insights into toxin levels and potential toxicity.
Source:

Analytica Chimica Acta, 1335, 343449
DOI:

https://doi.org/10.1016/j.aca.2024.343449
ISSN:

0003-2670
Format:

PDF
Publisher:

Elsevier BV
Document Type:

Journal Article
Rights Information:

Accepted Manuscript
Compliance:

Submitted
Main Document Checksum:

urn:sha-512:eb023b613be4e0dfcc5bba5f6237db5d7a99bad6e32ba16307c6666ddc6fbd0b2b35c65758fc53a78f65d09f891cbd9d8101a768f414220857dd8d00997e816d
Download URL:

https://repository.library.noaa.gov/view/noaa/70117/noaa_70117_DS1.pdf
File Type:

[PDF - 1.60 MB ]

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