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Consequences of HIV infection in the bone marrow niche
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2023
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Source: Frontiers in Immunology, 14
[PDF-3.07 MB]
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Journal Title:Frontiers in Immunology
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Description:Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV.
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Source:Frontiers in Immunology, 14
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ISSN:1664-3224
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Rights Information:CC BY
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Compliance:Library
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