Consequences of HIV infection in the bone marrow niche

Herd, Candice Lee; Mellet, Juanita; Mashingaidze, Tsungai; Durandt, Chrisna; Pepper, Michael Sean

doi:10.3389/fimmu.2023.1163012

i

Consequences of HIV infection in the bone marrow niche

2023
By Herd, Candice Lee ; Mellet, Juanita ; Mashingaidze, Tsungai ; ...

Details

Journal Title:

Frontiers in Immunology
Personal Author:

Herd, Candice Lee ; Mellet, Juanita ; Mashingaidze, Tsungai ; Durandt, Chrisna ; Pepper, Michael Sean
NOAA Program & Office:

NMFS (National Marine Fisheries Service)
Description:

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV.
Source:

Frontiers in Immunology, 14
DOI:

https://doi.org/10.3389/fimmu.2023.1163012
ISSN:

1664-3224
Format:

PDF
Publisher:

Frontiers Media SA
Document Type:

Journal Article
Funding:

Grant no. NA15NMF4270341
License:

https://creativecommons.org/licenses/by/4.0/
Rights Information:

CC BY
Compliance:

Library
Main Document Checksum:

urn:sha-512:2c5c917f44e2b194879f75236ac312eb3d5f60a56d615a9248d34f6f6631b37b0083bdfd819cde0e39cff9c369048e2c6a0a1309b2233b037eb6f90182afff12
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https://repository.library.noaa.gov/view/noaa/65401/noaa_65401_DS1.pdf
File Type:

[PDF - 3.07 MB ]

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