Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Gogineni, Vedanjali; Oh, Joonseok; Waters, Amanda L.; Kelly, Michelle; Stone, Robert; Hamann, Mark T.

doi:10.3389/fmars.2020.00058

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Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

2020
By Gogineni, Vedanjali ; Oh, Joonseok ; Waters, Amanda L. ; ...
Source: Frontiers in Marine Science, 7

[PDF-4.64 MB]

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Journal Title:

Frontiers in Marine Science
Personal Author:

Gogineni, Vedanjali ; Oh, Joonseok ; Waters, Amanda L. ; Kelly, Michelle ; Stone, Robert ; ... More +

Gogineni, Vedanjali ; Oh, Joonseok ; Waters, Amanda L. ; Kelly, Michelle ; Stone, Robert ; Hamann, Mark T. Less -
NOAA Program & Office:

AFSC (Alaska Fisheries Science Center) ; NMFS (National Marine Fisheries Service)

AFSC (Alaska Fisheries Science Center) ; NMFS (National Marine Fisheries Service) Less -
Description:

Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of Monanchora Carter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.
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Aquatic Science Global And Planetary Change Ocean Engineering Oceanography Water Science And Technology
Source:

Frontiers in Marine Science, 7
DOI:

https://doi.org/10.3389/fmars.2020.00058
ISSN:

2296-7745
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PDF
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Frontiers Media SA
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Journal Article
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https://creativecommons.org/licenses/by/4.0/
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CC BY
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urn:sha-512:65aa071b06ddf1614be31359eb09b148e6b53fc4a482ada41a7b809a59c5eb8e59cb618a99f0be723f47235d741d9b50923e433192c581a694a067057f114078
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Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

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