Modularity of genes involved in local adaptation to climate despite physical linkage

Lotterhos, Katie E; Yeaman, Sam; Degner, Jon; Aitken, Sally; Hodgins, Kathryn A

doi:10.1186/s13059-018-1545-7

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Modularity of genes involved in local adaptation to climate despite physical linkage

2018
By Lotterhos, Katie E ; Yeaman, Sam ; Degner, Jon ; ...
Source: Genome Biology, 19(1)

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Journal Title:

Genome Biology
Personal Author:

Lotterhos, Katie E ; Yeaman, Sam ; Degner, Jon ; Aitken, Sally ; Hodgins, Kathryn A

Lotterhos, Katie E ; Yeaman, Sam ; Degner, Jon ; Aitken, Sally ; Hodgins, Kathryn A Less -
NOAA Program & Office:

NEFSC (Northeast Fisheries Science Center) ; NMFS (National Marine Fisheries Service)

NEFSC (Northeast Fisheries Science Center) ; NMFS (National Marine Fisheries Service) Less -
Description:

Linkage among genes experiencing different selection pressures can make natural selection less efficient. Theory predicts that when local adaptation is driven by complex and non-covarying stresses, increased linkage is favored for alleles with similar pleiotropic effects, with increased recombination favored among alleles with contrasting pleiotropic effects. Here, we introduce a framework to test these predictions with a co-association network analysis, which clusters loci based on differing associations. We use this framework to study the genetic architecture of local adaptation to climate in lodgepole pine, Pinus contorta, based on associations with environments.
Source:

Genome Biology, 19(1)
DOI:

https://doi.org/10.1186/s13059-018-1545-7
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1474-760X
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PDF
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Springer Science and Business Media LLC
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Journal Article
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https://creativecommons.org/licenses/by/4.0/
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CC BY
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urn:sha-512:248779b5544ec031b0e6a065136500abbceb4b1a677e16941fcdf3050a260d3938662a6442bb0da1911442839aaf5af928097314cd530d49bb748bb7fa0eeb39
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Modularity of genes involved in local adaptation to climate despite physical linkage

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