Impacts of Fsh, Igf1, and high temperature on the expression of genes involved in steroidogenesis, cell communication, and apoptosis in isolated coho salmon previtellogenic ovarian follicles

Anderson, Kelli; Luckenbach, J. Adam; Yamamoto, Yoji; Elizur, Abigail

doi:10.1016/j.aquaculture.2019.03.025

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Impacts of Fsh, Igf1, and high temperature on the expression of genes involved in steroidogenesis, cell communication, and apoptosis in isolated coho salmon previtellogenic ovarian follicles

2019
By Anderson, Kelli ; Luckenbach, J. Adam ; Yamamoto, Yoji ; ...
Source: Aquaculture, 506, 60-69

[PDF-797.24 KB]

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Journal Title:

Aquaculture
Personal Author:

Anderson, Kelli ; Luckenbach, J. Adam ; Yamamoto, Yoji ; Elizur, Abigail

Anderson, Kelli ; Luckenbach, J. Adam ; Yamamoto, Yoji ; Elizur, Abigail Less -
NOAA Program & Office:

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center)

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center) Less -
Description:

In salmonids, exposure to elevated temperature impairs oogenesis. As such, there is a need to understand the molecular mechanisms that underpin this process, and develop mitigation strategies that maintain or rescue reproductive development in broodstock. In this study, follicle stimulating hormone (Fsh) and/or insulin-like growth factor 1 (Igf1) treatment were assessed for their ability to promote reproductive function at 14 and 22 °C in ovarian follicles from coho salmon in vitro. Maintenance at 22 °C resulted in the downregulation of fsh receptor, 17α-hydroxylase/C17,20-lyase and p450 aromatase a (cyp19a1a), and connexin 34.3 (cx34.3). While combined treatment with Fsh and Igf1 stimulated the expression of cyp19a1a at 14 °C, this treatment was not effective at 22 °C. Upregulation of cx34.3 occurred in response to treatments that contained Igf1 regardless of temperature, and there is evidence to suggest that apoptosis was inhibited to some extent at 22 °C following combined treatment with Fsh and Igf1. This study demonstrates the thermal impairment of key reproductive genes, and highlights the potential for novel hormone treatments to rescue oogenesis in salmonids.
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Aquatic Science
Source:

Aquaculture, 506, 60-69
DOI:

https://doi.org/10.1016/j.aquaculture.2019.03.025
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0044-8486
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Elsevier BV
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Journal Article
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urn:sha-512:a256838a9dedbe14e218c21357545bba8702bbdce01bd9d32f657746d470876c800110e0ff65e6008806902378baaaa33f3b3b995d28ffa6c7e874fed688c793
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Impacts of Fsh, Igf1, and high temperature on the expression of genes involved in steroidogenesis, cell communication, and apoptosis in isolated coho salmon previtellogenic ovarian follicles

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