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Genomes of an endangered rattlesnake show that neutral genetic variation predicts adaptive genetic variation and genetic load
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2023
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Source: Proceedings of the National Academy of Sciences, 120(49)
[PDF-13.83 MB]
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Journal Title:Proceedings of the National Academy of Sciences
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Description:One of the central tenets of conservation biology is that genetic variation is important to population viability. Small, isolated populations are expected to have lower genetic variation (e.g., heterozygosity), and more inbreeding (mating between relatives) than large, connected ones. Reduced genetic variation and higher inbreeding can reduce fitness (1). Numerous studies have demonstrated that inbreeding depression (lower fitness of more inbred individuals) can be strong (2) and reduce population growth (3–5). Most new mutations that affect protein structure are deleterious, and the constant input of new mutations means that all populations carry a “genetic load” (6). However, the genetic variation ultimately arising from mutation is essential for populations to adapt to changing ecological conditions (7). Avoiding problems associated with inbreeding depression and maintaining genetic variation and adaptive potential have long been viewed as key to conserving wild populations.
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Source:Proceedings of the National Academy of Sciences, 120(49)
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ISSN:0027-8424;1091-6490;
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Rights Information:CC BY-NC-ND
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