Metabolic programming mediated by an essential fatty acid alters body composition and survival skills of a marine fish

Fuiman, Lee A.; Perez, Kestrel O.

doi:10.1098/rspb.2015.1414

i

Metabolic programming mediated by an essential fatty acid alters body composition and survival skills of a marine fish

2015
By Fuiman, Lee A. ; Perez, Kestrel O.

Details

Journal Title:

Proceedings of the Royal Society B: Biological Sciences
Personal Author:

Fuiman, Lee A. ; Perez, Kestrel O.
NOAA Program & Office:

OAR (Oceanic and Atmospheric Research)
Description:

Metabolic programming occurs when variations in nutrition during a specific developmental window result in long-term metabolic effects. It has been studied almost exclusively in humans and other mammals but never in an ecological context. Here, we report metabolic programming and its functional consequences in a marine fish, red drum. We demonstrate that maternal provisioning of eggs with an essential fatty acid, docosahexaenoic acid (DHA), varies with DHA content of the maternal diet. When offspring are reared on a DHA-replete diet, whole-body DHA content of offspring depends upon the amount of DHA that was in the egg. We further demonstrate that whole-body DHA content is correlated with traits related to offspring fitness (escape responses, routine swimming, growth, and survival). DHA content of red drum eggs produced in nature is in the range where the effects of metabolic programming are most pronounced. Our findings indicate that during a brief developmental window, DHA plays a role in establishing the metabolic capacity for its own uptake or storage, with protracted and possibly permanent effects on ecologically important survival skills of individuals and important implications for dynamics of populations and food webs.
Keywords:

General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology General Environmental Science General Immunology And Microbiology General Medicine General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology General Immunology And Microbiology General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology General Immunology And Microbiology
Source:

Proceedings of the Royal Society B: Biological Sciences, 282(1819), 20151414
DOI:

https://doi.org/10.1098/rspb.2015.1414
ISSN:

0962-8452 ; 1471-2954
Format:

PDF
Publisher:

The Royal Society
Document Type:

Journal Article
Funding:

Grant no. NA10OAR4170099
Rights Information:

Other
Compliance:

Library
Main Document Checksum:

urn:sha256:71572b8272ac54937bb5ae35349873a2d2debde6dbfa632b24e02ccc4fce53d0
Download URL:

https://repository.library.noaa.gov/view/noaa/59990/noaa_59990_DS1.pdf
File Type:

[PDF - 465.88 KB ]

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