Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production

Steele, Taylor S.; Brunson, John K.; Maeno, Yukari; Terada, Ryuta; Allen, Andrew E.; Yotsu-Yamashita, Mari; Chekan, Jonathan R.; Moore, Bradley S.

doi:10.1073/pnas.2117407119

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Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production

2022
By Steele, Taylor S. ; Brunson, John K. ; Maeno, Yukari ; ...
Source: Proceedings of the National Academy of Sciences, 119(6)

[PDF-1.28 MB]

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Proceedings of the National Academy of Sciences
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Steele, Taylor S. ; Brunson, John K. ; Maeno, Yukari ; Terada, Ryuta ; Allen, Andrew E. ; ... More +

Steele, Taylor S. ; Brunson, John K. ; Maeno, Yukari ; Terada, Ryuta ; Allen, Andrew E. ; Yotsu-Yamashita, Mari ; Chekan, Jonathan R. ; Moore, Bradley S. Less -
NOAA Program & Office:

OAR (Oceanic and Atmospheric Research)
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Significance Originally isolated from the red alga Chondria armata , domoic acid (DA) is best known as a potent marine neurotoxin produced by oceanic harmful algal blooms of planktonic diatoms. Sequencing efforts to date of kainoid-producing red algae have focused exclusively on a closely related molecule, kainic acid, leaving a gap in the understanding of DA biosynthesis in red algae and its evolutionary linkage to diatoms. Here, we present the phylogenetic and biochemical investigation of DA biosynthesis in C. armata . This work demonstrates the high synteny of DA biosynthetic genes between relatively distant taxonomic groups of algae and suggests a complex evolutionary history for DA biosynthesis involving gene transfer and neofunctionalization.
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Multidisciplinary
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Proceedings of the National Academy of Sciences, 119(6)
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https://doi.org/10.1073/pnas.2117407119
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0027-8424;1091-6490;
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Proceedings of the National Academy of Sciences
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Journal Article
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Grant no. NA19NOS4780181
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https://creativecommons.org/licenses/by-nc-nd/4.0/
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CC BY-NC-ND
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urn:sha256:a2d2077f9293b3114e0c60510fd97cf0c7e362075d0989341506a8c34677f0bc
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Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production

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