Allelic diversification after transposable element exaptation promotedgsdfas the master sex determining gene of sablefish

Herpin, Amaury; Schartl, Manfred; Depincé, Alexandra; Guiguen, Yann; Bobe, Julien; Hua-Van, Aurélie; Hayman, Edward S.; Octavera, Anna; Yoshizaki, Goro; Nichols, Krista M.; Goetz, Giles W.; Luckenbach, J. Adam

doi:10.1101/gr.274266.120

i

Allelic diversification after transposable element exaptation promotedgsdfas the master sex determining gene of sablefish

2021
By Herpin, Amaury ; Schartl, Manfred ; Depincé, Alexandra ; ...

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Journal Title:

Genome Research
Personal Author:

Herpin, Amaury ; Schartl, Manfred ; Depincé, Alexandra ; Guiguen, Yann ; Bobe, Julien ; Hua-Van, Aurélie ; Hayman, Edward S. ; Octavera, Anna ; Yoshizaki, Goro ; Nichols, Krista M. ; Goetz, Giles W. ; Luckenbach, J. Adam
NOAA Program & Office:

NOAA General Documents
Description:

Concepts of evolutionary biology suggest that morphological change may occur by rare punctual but rather large changes, or by more steady and gradual transformations. It can therefore be asked whether genetic changes underlying morphological, physiological, and/or behavioral innovations during evolution occur in a punctual manner, whereby a single mutational event has prominent phenotypic consequences, or if many consecutive alterations in the DNA over longer time periods lead to phenotypic divergence. In the marine teleost, sablefish (Anoplopoma fimbria), complementary genomic and genetic studies led to the identification of a sex locus on the Y Chromosome. Further characterization of this locus resulted in identification of thetransforming growth factor, beta receptor 1a(tgfbr1a) gene,gonadal somatic cell derived factor(gsdf), as the main candidate for fulfilling the master sex determining (MSD) function. The presence of different X and Y Chromosome copies of this gene indicated that the male heterogametic (XY) system of sex determination in sablefish arose by allelic diversification. ThegsdfYgene has a spatio-temporal expression profile characteristic of a male MSD gene. We provide experimental evidence demonstrating a pivotal role of a transposable element (TE) for the divergent function ofgsdfY. By insertion within thegsdfYpromoter region, this TE generated allelic diversification by bringingcis-regulatory modules that led to transcriptional rewiring and thus creation of a new MSD gene. This points out, for the first time in the scenario of MSD gene evolution by allelic diversification, a single, punctual molecular event in the appearance of a new trigger for male development.
Keywords:

Genetics Genetics (clinical)
Source:

Genome Research, 31(8), 1366-1380
DOI:

https://doi.org/10.1101/gr.274266.120
ISSN:

1088-9051 ; 1549-5469
Format:

PDF
Publisher:

Cold Spring Harbor Laboratory
Pubmed ID:

34183453
Pubmed Central ID:

PMC8327909
Document Type:

Journal Article
License:

https://creativecommons.org/licenses/by-nc/4.0/
Rights Information:

CC BY-NC
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Library
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urn:sha256:6282b06bf0e4fced0bb3dbad5680c24742eef032908b96d191be9dc32ceff957
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https://repository.library.noaa.gov/view/noaa/59264/noaa_59264_DS1.pdf
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[PDF - 8.74 MB ]

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