Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops truncatus), an Essential Step in the Conservation of at-Risk Dolphins

Barratclough, Ashley; Smith, Cynthia R.; Gomez, Forrest M.; Photopoulou, Theoni; Takeshita, Ryan; Pirotta, Enrico; Thomas, Len; McClain, Abby M.; Parry, Celeste; Zoller, Joseph A.; Horvath, Steve; Schwacke, Lori H.

doi:10.3390/jzbg2030030

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Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops truncatus), an Essential Step in the Conservation of at-Risk Dolphins

2021
By Barratclough, Ashley ; Smith, Cynthia R. ; Gomez, Forrest M. ; ...
Source: Journal of Zoological and Botanical Gardens, 2(3), 416-420

[PDF-564.45 KB]

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Journal Title:

Journal of Zoological and Botanical Gardens
Personal Author:

Barratclough, Ashley ; Smith, Cynthia R. ; Gomez, Forrest M. ; Photopoulou, Theoni ; Takeshita, Ryan ; ... More +

Barratclough, Ashley ; Smith, Cynthia R. ; Gomez, Forrest M. ; Photopoulou, Theoni ; Takeshita, Ryan ; Pirotta, Enrico ; Thomas, Len ; McClain, Abby M. ; Parry, Celeste ; Zoller, Joseph A. ; Horvath, Steve ; Schwacke, Lori H. Less -
NOAA Program & Office:

NMFS (National Marine Fisheries Service)
Description:

Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R2 = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics.
Keywords:

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General Medicine
Source:

Journal of Zoological and Botanical Gardens, 2(3), 416-420
DOI:

https://doi.org/10.3390/jzbg2030030
ISSN:

2673-5636
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PDF
Publisher:

MDPI AG
Document Type:

Journal Article
Funding:

Grant no. NA20NMF4390132
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https://creativecommons.org/licenses/by/4.0/
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CC BY
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urn:sha256:425821164b3f3aa273a5d50658f98f25eb3ac2314e5d6f8bfbf1d34dddc62983
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https://staging-noaa.cdc.gov/view/noaa/58677/noaa_58677_DS1.pdf
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Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops truncatus), an Essential Step in the Conservation of at-Risk Dolphins

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