Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease

Ushijima, Blake; Gunasekera, Sarath P.; Meyer, Julie L.; Tittl, Jessica; Pitts, Kelly A.; Thompson, Sharon; Sneed, Jennifer M.; Ding, Yousong; Chen, Manyun; Jay Houk, L.; Aeby, Greta S.; Häse, Claudia C.; Paul, Valerie J.

doi:10.1038/s42003-023-04590-y

i

Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease

2023
By Ushijima, Blake ; Gunasekera, Sarath P. ; Meyer, Julie L. ; ...

Details

Journal Title:

Communications Biology
Personal Author:

Ushijima, Blake ; Gunasekera, Sarath P. ; Meyer, Julie L. ; Tittl, Jessica ; Pitts, Kelly A. ; Thompson, Sharon ; Sneed, Jennifer M. ; Ding, Yousong ; Chen, Manyun ; Jay Houk, L. ; Aeby, Greta S. ; Häse, Claudia C. ; Paul, Valerie J.
NOAA Program & Office:

CoRIS (Coral Reef Information System) ; OAR (Oceanic and Atmospheric Research)
Description:

Considered one of the most devastating coral disease outbreaks in history, stony coral tissue loss disease (SCTLD) is currently spreading throughout Florida’s coral reefs and the greater Caribbean. SCTLD affects at least two dozen different coral species and has been implicated in extensive losses of coral cover. Here we show Pseudoalteromonas sp. strain McH1-7 has broad-spectrum antibacterial activity against SCTLD-associated bacterial isolates. Chemical analyses indicated McH1-7 produces at least two potential antibacterials, korormicin and tetrabromopyrrole, while genomic analysis identified the genes potentially encoding an L-amino acid oxidase and multiple antibacterial metalloproteases (pseudoalterins). During laboratory trials, McH1-7 arrested or slowed disease progression on 68.2% of diseased Montastraea cavernosa fragments treated (n = 22), and it prevented disease transmission by 100% (n = 12). McH1-7 is the most chemically characterized coral probiotic that is an effective prophylactic and direct treatment for the destructive SCTLD as well as a potential alternative to antibiotic use.
Keywords:

General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology Medicine (miscellaneous) General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology General Agricultural And Biological Sciences General Biochemistry, Genetics And Molecular Biology
Source:

Communications Biology, 6(1)
DOI:

https://doi.org/10.1038/s42003-023-04590-y
ISSN:

2399-3642
Format:

PDF
Publisher:

Springer Science and Business Media LLC
Document Type:

Journal Article
Funding:

Grant no. NA19NOS4820114
License:

https://creativecommons.org/licenses/by/4.0/
Rights Information:

CC BY
Compliance:

Library
Main Document Checksum:

urn:sha256:0320e061b4635d059fd81f700b51159101848a7917c80c2712bbf7132fcaac05
Download URL:

https://repository.library.noaa.gov/view/noaa/58593/noaa_58593_DS1.pdf
File Type:

[PDF - 4.93 MB ]

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