U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

The effect of Ochratoxin A on antimicrobial polypeptide expression and resistance to water mold infection in channel catfish (Ictalurus punctatus)



Details

  • Journal Title:
    Fish & Shellfish Immunology
  • Personal Author:
    Zahran, Eman ORCID ICON IMG ; Manning, Bruce ; Seo, Jung-Kil ; Noga, Edward J.
  • NOAA Program & Office:
    NOAA General Documents
  • Description:
    Mycotoxin contamination of agricultural commodities poses a serious risk to animal health, including aquaculture species. Ochratoxin A (OA) is the most immunotoxic ochratoxin, yet little is known about its effect on immune function in fish. Antimicrobial polypeptides (AMPPs) are one of the most potent, innate, host defense factors, yet very little is known about what types of chronic stressors affect their expression. Among the most prevalent and potent AMPPs in fish are histone-like proteins (HLPs). In this study, fish were fed 2, 4, or 8 mg OA/kg diet. Skin antibacterial activity and HLP-1 levels were measured on Days 0, 28 and 56. Feeding 2, 4 or 8 mg OA/kg diet resulted in significant growth depression, but higher levels (4 or 8 mg OA/kg diet) resulted in lowering feed intake (FI) and impaired feed conversion ratio. In addition, feeding 8 mg OA/kg diet increased susceptibility to experimental water mold (Saprolegnia) challenge, suggesting that OA toxicity might contribute to some saprolegnosis outbreaks. However, there were no changes in AMPP expression in any treatment group. Our data suggests that the increased disease susceptibility of channel catfish due to OA is probably due to mechanisms other than a direct effect on antimicrobial polypeptide expression.
  • Keywords:
  • Source:
    Fish & Shellfish Immunology, 57, 60-67
  • DOI:
    https://doi.org/10.1016/j.fsi.2016.08.034
  • ISSN:
    1050-4648
  • Format:
    PDF
  • Publisher:
    Elsevier BV
  • Document Type:
    Journal Article
  • Rights Information:
    Accepted Manuscript
  • Compliance:
    Library
  • Download URL:
    https://repository.library.noaa.gov/view/noaa/57576/noaa_57576_DS1.pdf
  • File Type:
    Filetype[PDF - 771.85 KB]
  • Collection(s):
    NOAA General Documents
  • Main Document Checksum:
    urn:sha256:63803194a5960e58c845a896c7aea0443473ffd7500f9f1318758f634108cee4
PREVIOUS
ON THIS PAGE
Details
 Found an issue?
Send us an email at:
noaa.repository@noaa.gov
The NOAA IR serves as an archival repository of NOAA-published products including scientific findings, journal articles, guidelines, recommendations, or other information authored or co-authored by NOAA or funded partners. As a repository, the NOAA IR retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP