Gene Expression On The Fly: A Transcriptome-Level View Of Drosophila's Immune Response To The Opportunistic Fungal Pathogen Aspergillus Flavus
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

For very narrow results

When looking for a specific result

Best used for discovery & interchangable words

Recommended to be used in conjunction with other fields

Dates

to

Document Data
Library
People
Clear All
Clear All

For additional assistance using the Custom Query please check out our Help Page

The NOAA IR serves as an archival repository of NOAA-published products including scientific findings, journal articles, guidelines, recommendations, or other information authored or co-authored by NOAA or funded partners. As a repository, the NOAA IR retains documents in their original published format to ensure public access to scientific information.
i

Gene Expression On The Fly: A Transcriptome-Level View Of Drosophila's Immune Response To The Opportunistic Fungal Pathogen Aspergillus Flavus

Filetype[PDF-3.17 MB]


Details You May Also Like

Details:

  • Journal Title:
    Infection, Genetics and Evolution
  • Personal Author:
  • NOAA Program & Office:
  • Sea Grant Program:
    PRU (Puerto Rico Sea Grant)
  • Description:
    Aspergilloses are opportunistic infections in animals and humans caused by several Aspergillus species, including Aspergillus flavus. Although the immune system of Drosophila melanogaster is extensively studied, little is known about the fly's specific responses to infection by A. flavus. We compared gene expression levels during induced infections in D. melanogaster by a virulent A. flavus isolate and a less virulent isolate, as well as from uninfected flies as a control. We found that 1081 of the 14,554 gene regions detected were significantly differentially expressed among treatments. Some of these up- and down- regulated genes were previously shown to be involved in defense responses against pathogens. Some are known to be involved in vitelline membrane formation in flies. Other up- and down-regulated genes are of unknown function. Understanding expression of these genes during the process of infection in flies should improve our knowledge of innate immunity in invertebrates, and by extension, in vertebrates as well.
  • Keywords:
  • Source:
    Infection, Genetics and Evolution, 82: 104308
  • DOI:
  • Document Type:
    Journal Article
  • Funding:
    Grant no. NA18OAR4170089
  • Rights Information:
    Accepted Manuscript
  • Rights Statement:
    The NOAA IR provides access to this content under the authority of the government's retained license to distribute publications and data resulting from federal funding. While users may legally access this content, the copyright owners retain rights that govern the reproduction, redistribution, and re-use of this work. The user is solely responsible for complying with applicable copyright law.
  • Compliance:
    Submitted
  • Main Document Checksum:
  • Download URL:
  • File Type:

Supporting Files

  • No Additional Files
More +

You May Also Like

Checkout today's featured content at

Version 3.27.2