Comparative tissue distribution of cadmium in mice dosed with partially purified extracts of oyster
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Comparative tissue distribution of cadmium in mice dosed with partially purified extracts of oyster

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    Two experiments were conducted to examine the relative tissue distribution of ingested cadmium (Cd) from edible oyster tissue. In the first experiment, oysters containing high or low, concentrations of Cd were extracted in physiological buffer and the intact oyster, supernatant, or pellet were incorporated into diets at levels that would give equal Cd, concentrations to each diet. Cadmium chloride was added to low Cd oyster diets to increase the Cd level to that found in the high Cd oyster diets. All diets were balanced for several constituents, including metals, and fed to mice for 7 days. Cadmium deposition in liver, kidney, duodenum, jejunum ileum, and femur were similar for all treatments. Excretion of Cd was lower via the feces and higher via the urine in mice fed Cd occurring in the oyster pellet compared to mice fed intact oyster or oyster supernatant fractions. In the second experiment, the major soluble chemical form of Cd occurring in the oyster tissue was partially purified by a combination of centrifugation, gel permeation and ion exchange chromatography, and ultrafiltration. techniques. Metals were measured in the extract by atomic absorption spectrophotometry or anodic stripping voltammetry. Amino acids were identified in the/extract by reverse phase HPLC and thin layer chromatography. Mice were gavaged with the extract and compared to mice gavaged with combinations of chemically pure sources of the metals and amino acids. Mice dosed with intrinsic oyster Cd retained greater than 4 times more Cd in their livers and greater than 3 times more Cd in their kidneys than any other treatment. Mice dosed with CdCl2 and L-taurine retained more Cd in jejunum-ileum than the other treatments. Duodenal retention of Cd was similar in all treatments. The results suggest that the major soluble form of Cd in dietary oyster has a high affinity for tissues critical to Cd toxicity.
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