Seasonal Influenza Infections and Cardiovascular Disease Mortality

Details

• Journal Title:
  JAMA Cardiology
• Personal Author:
  Nguyen, Jennifer L. ; Yang, Wan ; Ito, Kazuhiko ; Matte, Thomas D. ; Shaman, Jeffrey ; Kinney, Patrick L.
• NOAA Program & Office:
  OAR (Oceanic and Atmospheric Research)
• Description:
  Among adults 65 years and older, who accounted for 83.0% (73 363 deaths) of nonpandemic cardiovascular mortality during influenza seasons, seasonal average influenza incidence was correlated year to year with excess cardiovascular mortality (Pearson correlation coefficients ≥0.75, P ≤ .05 for 4 different influenza indicators). In daily time-series analyses using 4 different influenza metrics, interquartile range increases in influenza incidence during the previous 21 days were associated with an increase between 2.3% (95% CI, 0.7%-3.9%) and 6.3% (95% CI, 3.7%-8.9%) for cardiovascular disease mortality and between 2.4% (95% CI, 1.1%-3.6%) and 6.9% (95% CI, 4.0%-9.9%) for ischemic heart disease mortality among adults 65 years and older. The associations were most acute and strongest for myocardial infarction mortality, with each interquartile range increase in influenza incidence during the previous 14 days associated with mortality increases between 5.8% (95% CI, 2.5%-9.1%) and 13.1% (95% CI, 5.3%-20.9%). Out-of-sample prediction of cardiovascular mortality among adults 65 years and older during the 2009-2010 influenza season yielded average estimates with 94.0% accuracy using 4 different influenza metrics.
• Keywords:
  Influenza Mortality Seasonality
• Source:
  JAMA Cardiol. 2016 Jun 1; 1(3): 274–281.
• DOI:
  https://doi.org/10.1001/jamacardio.2016.0433
• Pubmed ID:
  27438105
• Pubmed Central ID:
  PMC5158013
• Document Type:
  Journal Article
• Funding:
  Grant no. NA10OAR4310212
• Compliance:
  PMC
• Main Document Checksum:
  urn:sha256:9bf3f50976ff92a2eee49e4bbd9c9219ad0b0008c9152c0a4b5d12af86fc6f92
• File Type: