Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways

Matsushita, Yoshiyuki; Miyoshi, Kaho; Kabeya, Naoki; Sanada, Shuwa; Yazawa, Ryosuke; Haga, Yutaka; Satoh, Shuichi; Yamamoto, Yoji; Strüssmann, Carlos Augusto; Luckenbach, John Adam; Yoshizaki, Goro

doi:10.1038/s42003-020-01242-3

i

Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways

2020
By Matsushita, Yoshiyuki ; Miyoshi, Kaho ; Kabeya, Naoki ; ...

Details

Journal Title:

Communications Biology
Personal Author:

Matsushita, Yoshiyuki ; Miyoshi, Kaho ; Kabeya, Naoki ; Sanada, Shuwa ; Yazawa, Ryosuke ; Haga, Yutaka ; Satoh, Shuichi ; Yamamoto, Yoji ; Strüssmann, Carlos Augusto ; Luckenbach, John Adam ; Yoshizaki, Goro
NOAA Program & Office:

NMFS (National Marine Fisheries Service) ; NWFSC (Northwest Fisheries Science Center)
Description:

The colonisation of freshwater environments by marine fishes has historically been considered a result of adaptation to low osmolality. However, most marine fishes cannot synthesise the physiologically indispensable fatty acid, docosahexaenoic acid (DHA), due to incomplete DHA biosynthetic pathways, which must be adapted to survive in freshwater environments where DHA is poor relative to marine environments. By analysing DHA biosynthetic pathways of one marine and three freshwater-dependent species from the flatfish family Achiridae, we revealed that functions of fatty acid metabolising enzymes have uniquely and independently evolved by multi-functionalisation or neofunctionalisation in each freshwater species, such that every functional combination of the enzymes has converged to generate complete and functional DHA biosynthetic pathways. Our results demonstrate the elaborate patchwork of fatty acid metabolism and the importance of acquiring DHA biosynthetic function in order for fish to cross the nutritional barrier at the mouth of rivers and colonise freshwater environments.
Keywords:

Flatfishes Freshwater Habitats Freshwater Habitats
Source:

Commun Biol. 2020 Sep 18;3(1):516.
DOI:

https://doi.org/10.1038/s42003-020-01242-3
Pubmed ID:

32948803
Pubmed Central ID:

PMC7501227
Document Type:

Journal Article
Rights Information:

CC BY
Compliance:

PMC
Main Document Checksum:

urn:sha256:9cbddf2852c436a7186e820712e20052ff75696cf7a6f2644d3c97b9b1e64808
Download URL:

https://repository.library.noaa.gov/view/noaa/27518/noaa_27518_DS1.pdf
File Type:

[PDF - 1.45 MB ]

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