Toward the identification, characterization and experimental culture of Lacazia loboi from Atlantic bottlenose dolphin (Tursiops truncatus)

Schaefer, Adam M.; Reif, John S.; Guzmán, Esther A.; Bossart, Gregory D.; Ottuso, Patrick; Snyder, Joseph; Medalie, Neil; Rosato, Ralph; Han, Sushan; Fair, Patricia A.; McCarthy, Peter J.

doi:10.1093/mmy/myw011

i

Toward the identification, characterization and experimental culture of Lacazia loboi from Atlantic bottlenose dolphin (Tursiops truncatus)

2016
By Schaefer, Adam M. ; Reif, John S. ; Guzmán, Esther A. ; ...

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Journal Title:

Medical Mycology
Personal Author:

Schaefer, Adam M. ; Reif, John S. ; Guzmán, Esther A. ; Bossart, Gregory D. ; Ottuso, Patrick ; Snyder, Joseph ; Medalie, Neil ; Rosato, Ralph ; Han, Sushan ; Fair, Patricia A. ; McCarthy, Peter J.
NOAA Program & Office:

NOS (National Ocean Service)
Description:

Lobomycosis (lacaziosis) is a chronic, granulomatous, fungal infection of the skin and subcutaneous tissues of humans and dolphins. To date, the causative agent, the yeast-like organism Lacazia loboi, has not been grown in the laboratory, and there have been no recent reports describing attempts to culture the organism. As a result, studies on the efficacy of therapeutics and potential environmental reservoirs have not been conducted. Therefore, the objective of the current study was to utilize both classical and novel microbiological methods in order to stimulate growth of Lacazia cells collected from dolphin lesions. This included the experimental inoculation of novel media, cell culture, and the use of artificial skin matrices. Although unsuccessful, the methods and results of this study provide important insight into new approaches that could be utilized in future investigations of this elusive organism.
Source:

Medical Mycology, 54(6), 659-665.
DOI:

https://doi.org/10.1093/mmy/myw011
Document Type:

Journal Article
Rights Information:

CC BY
Compliance:

Submitted
Main Document Checksum:

urn:sha256:9f1acbe4f83cad870a20cdf336cbd4f679549d406fb913d8d55adb463634b8c6
Download URL:

https://repository.library.noaa.gov/view/noaa/13800/noaa_13800_DS1.pdf
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[PDF - 760.86 KB ]

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